Immune control of brain physiology

2025/01/31 by Mariángeles Kovacs, Amaia Dominguez-Belloso, Samir Ali-Moussa +1 · 1 voice · 2 citations
Neuroscience · #Neuroinflammation and Neurodegeneration Mechanisms #Neuroscience and Neuropharmacology Research #Vagus Nerve Stimulation Research

paper · doi:10.1038/s41577-025-01129-6

openalex publication_date 2025/01/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Citations

• A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
• A size selective vascular barrier in the rat area postrema formed by perivascular macrophages and the extracellular matrix
• Functional characterization of the dural sinuses as a neuroimmune interface
• An aged immune system drives senescence and ageing of solid organs
• Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
• T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis

Cited by

• Keep your neutrophils close, but your mast cells closer
• Meningeal blood vessel blockage enhances anti-glioblastoma immunity

Discussions

• I must admit, I never quite knew how to imagine functional immune–brain crosstalk in situ. Thanks to our good friends at @aleksdelab.bsky.social, I can now read and see in @natrevimmunol.nature.com! [bsky, 12 points, 1 comments]