2021/06/07 by Kwang Sik Suh, Suk Chon, Woon Won Jung +1
Biochemistry, Genetics and Molecular Biology · Medicine · #Advanced Glycation End Products research #Alzheimer's disease research and treatments #Genomics, phytochemicals, and oxidative stress
paper · doi:10.1002/jat.4211
openalex publication_date 2021/06/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Abstract The accumulation of advanced glycation end products (AGEs) causes metabolic dysfunction and neuronal cell damage. Methylglyoxal (MG) is a major glycating agent that reacts with basic residues present in proteins and promotes the formation of AGEs. Sciadopitysin, a type of biflavonoid, exerts protective effects against neuronal cell damage; however, the underlying mechanisms have not been studied. This study aimed to investigate the mechanisms underlying the protective effects of sciadopitysin against MG‐mediated cytotoxicity in SK‐N‐MC neuroblastoma cells. Our results demonstrated that pretreatment of SK‐N‐MC cells with sciadopitysin improved the cell viability that was inhibited by MG and inhibited the apoptosis induced by MG. Sciadopitysin attenuated intracellular Ca 2+ , NOX4 levels, oxidative stress, and MG‐protein adduct levels, and increased nuclear Nrf2 and glyoxalase 1 levels in the presence of MG. These results suggest that sciadopitysin exerts neuroprotective effects against MG‐induced death of human SK‐N‐MC cells via its antioxidative action. This study highlights sciadopitysin as a promising candidate for antioxidant therapy and designing natural drugs against AGE‐induced neurodegenerative disorders.