Discovery of thiobarbiturate-indole scaffold as a selective inhibitor targeting chikungunya virus nsP3 macrodomain through a cryptic binding pocket

2026/07/01 by Men Thi Hoai Duong, Tomi A.O. Parviainen, Tomi A. O. Parviainen +5
Biochemistry, Genetics and Molecular Biology · Medicine · #Cell death mechanisms and regulation #Malaria Research and Control #Mosquito-borne diseases and control

paper · doi:10.1016/j.ejmech.2026.119182

openalex publication_date 2026/07/22 · openalex created_date 2026/07/23 · openalex updated_date 2026/07/31

Citations

• Simultaneous Inference in General Parametric Models
• Phasercrystallographic software
• Macrodomains: Structure, Function, Evolution, and Catalytic Activities
• Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation