2025/10/08 by Elise Caron, Charlotte Rozenberg, Johann Peltier +4
Medicine · Neuroscience · #Cerebrospinal fluid and hydrocephalus #Fetal and Pediatric Neurological Disorders #Spinal Dysraphism and Malformations
paper · doi:10.1016/j.neuchi.2025.101734
openalex publication_date 2025/10/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/26
• The DESH score is a score based on morphological analysis of the subarachnoid spaces and ventricles. This score is based on the finding of ventricular dilatation associated with a disproportionate distribution of CSF between the subarachnoid spaces from the base to the vertex. This description is combined with the measurement of the classical acute angle of the corpus callosum in Hakim disease. This score is made up of qualitative and quantitative elements. This score would allow a quantitative analysis and therefore potentially useful in the objective diagnosis of chronic hydrocephalus. • Our study shows the interest of this score via its reproducibility, but above all highlights the parameters of this score that are the most reproducible and therefore potentially the most useful in the diagnostic approach. idiopathic chronic hydrocephalus (iCH) is underdiagnosed in older adults. The diagnosis of iCH is important because effective surgical treatment is available. Indeed, iCH is the only curable dementia. The disproportionately enlarged subarachnoid space hydrocephalus (DESH) score was recently developed on the basis of morphologic MRI data, as a guide to the diagnosis of iCH in adults. In a population of 68 patients having undergone placement of a ventriculoperitoneal shunt, the preoperative DESH score was calculated retrospectively by a senior neurosurgeon and a neurosurgery resident. To analyze inter-observer variability, the results obtained for each patient were compared. We calculated sensitivity, specificity, positive and negative predictive values of the DESH score. DESH score of 7 or more present the best diagnostic performance (sensitivity: 83%, specificity: 40%, positive predictive value: 89%, negative predictive value: 29%). The interobserver reliability of the DESH score was excellent, with an intraclass correlation coefficient of 0.936. Similarly, the levels of interobserver agreement for each individual item were fair (for Sylvian fissure dilatation, local focal sulci dilatation, and tight high convexity) to excellent (for the callosal angle). The DESH score is a reliable score obtained by studying brain MRI and radiographic datasets. The score’s excellent reliability means that it can be included in the routine diagnosis of iCH.