Central lipid sensing pathways contribute to the control of puberty and its alterations in conditions of obesity

2025/04/02 by Elvira Rodríguez-Vázquez, Álvaro Aranda-Torrecillas, María López-Sancho +12
Medicine · Neuroscience · #Adipose Tissue and Metabolism #Apelin-related biomedical research #Regulation of Appetite and Obesity

paper · doi:10.1152/ajpendo.00493.2024

openalex publication_date 2025/04/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Puberty is highly sensitive to body energy status, and child obesity is often linked to perturbed puberty. However, whether this comes from excessive energy stores or specific nutrient signals altered in obesity remains largely unexplored. Using suitable preclinical models of early obesity and accelerated puberty, we disclose herein conclusive evidence for altered hypothalamic lipid profiles and the roles of specific lipid-sensing pathways in pubertal control, with a variable contribution depending on the maturational and nutritional status.

Citations

• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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