2024/03/20 by Xiang Shen, Ziqi Yu, Changli Wei +2
Medicine · #Ferroptosis and cancer prognosis #Iron Metabolism and Disorders #Liver Disease Diagnosis and Treatment
paper · doi:10.1152/ajpendo.00260.2023
openalex publication_date 2024/03/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease with increasing prevalence worldwide. NAFLD could develop from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), NASH-related fibrosis, cirrhosis, and even hepatocellular carcinoma. However, the mechanism of NAFLD development has not yet been fully defined. Recently, emerging evidence shows that the dysregulated iron metabolism marked by elevated serum ferritin, and ferroptosis are involved in the NAFLD. Understanding iron metabolism and ferroptosis can shed light on the mechanisms of NAFLD development. Here, we summarized studies on iron metabolism and the ferroptosis process involved in NAFLD development to highlight potential medications and therapies for treating NAFLD.