2025/05/01 by Jie Pan, Rongqiang Wu, Liuyang He +8
Biochemistry, Genetics and Molecular Biology · Medicine · #Chemokine receptors and signaling #Diabetes and associated disorders #Salivary Gland Disorders and Functions
paper · doi:10.1016/j.imbio.2025.152914
openalex publication_date 2025/05/01 · openalex created_date 2025/05/16 · openalex updated_date 2026/07/25
In this study, we found that the CD8 + CD45RA + CCR7 − T cell subpopulation was increased in the peripheral blood of patients with primary Sjögren's syndrome (pSS) compared with healthy donors. Moreover, both CD8 + TIM-3 + T cells and CD8 + CD45RA + CCR7 − T cells were positively correlated with serum anti-SSA antibody concentrations in patients. In animal experiments, prolonged administration of β-glucan (whole glucan particle [WGP]) effectively reduced the onset and progression of pSS. Compared with the control group, the WGP-treated group showed a significant reduction in the proportions of CD4 + PD-1 + T cells, CD4 + TIM-3 + T cells, CD8 + PD-1 + T cells, CD8 + TIM-3 + T cells, and CD8 + CD45RA + CCR7 − T cells in the spleens and peripheral blood of non-obese diabetic mice. Notably, β-glucan exhibited therapeutic efficacy comparable to that of hydroxychloroquine sulfate, a conventional treatment for pSS. These findings suggest that the CD8 + CD45RA + CCR7 − T cell subpopulation may represent a promising new therapeutic target for the disease.