2021/02/02 by Nathalie Picollet-D’hahan, Agnieszka Zuchowska, Agnieszka Żuchowska +2 · 3 citations
Engineering · Neuroscience · #3D Printing in Biomedical Research #Innovative Microfluidic and Catalytic Techniques Innovation #Neuroscience and Neural Engineering
paper · pdf · doi:10.1016/j.tibtech.2020.11.014
openalex publication_date 2021/02/02 · openalex created_date 2021/02/15 · openalex updated_date 2026/07/29
Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which human health research is conducted. After briefly reviewing the need for comprehensive multiorgan models with a systemic dimension, we highlight scenarios in which multiorgan models are advantageous. We next overview existing multi-OoC platforms, including integrated body-on-a-chip devices and modular approaches involving interconnected organ-specific modules. We highlight how multi-OoC models can provide unique information that is not accessible using single-OoC models. Finally, we discuss remaining challenges for the realization of multi-OoC platforms and their worldwide adoption. We anticipate that multi-OoC technology will metamorphose research in biology and medicine by providing holistic and personalized models for understanding and treating multisystem diseases.