2025/09/09 by Margarita Bernal-Cabas, Karan Kumar, Owen T Terpstra +10 · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · #Anaerobic Digestion and Biogas Production #Biofuel production and bioconversion #Microbial Metabolic Engineering and Bioproduction
paper · doi:10.1016/j.tibtech.2025.08.003
openalex publication_date 2025/09/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
) into biomass via gas fermentation, a process already used for food-grade single-cell protein production. This approach enables a supply chain independent of agriculture, requiring minimal land and water, with potential for carbon-neutral production and carbon capture. To expand beyond single-cell protein, HOBs must be engineered into cell factories for precision fermentation. Advances in synthetic biology, metabolic engineering, computational modelling, and bioreactor design have accelerated the development of scalable bioprocesses providing a blueprint for gas-based fermentation. We present a path forward using secreted recombinant milk protein as a case study, highlighting key challenges and opportunities.