2024/12/09 by Heng Zhou, Zhou, Heng, Linda Sun +5
Engineering · #Sports Dynamics and Biomechanics
paper · pdf · doi:10.48550/arxiv.2412.06622
The oncology exploratory basket trial design with pruning and pooling (P&P) approach has gained increasing popularity in recent years for its simplicity and efficiency. This method was proposed based on binary endpoint, limiting its wider application. This short communication proposed a generalized framework of using P-value combination test to implement pruning and pooling process in basket trials. Only P-values of any type of statistical testing from each cohort are needed for decision making, which provides great flexibility for basket trial designs with P&P approach.