Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6Clow F4/80+ Extratumoral Macrophages

2015/04/15 by Gregory L. Beatty, Rafael Winograd, Rebecca A. Evans +10 · 29 citations
Immunology and Microbiology · Medicine · #Immunotherapy and Immune Responses #Cancer Immunotherapy and Biomarkers #CAR-T cell therapy research

paper · doi:10.1053/j.gastro.2015.04.010

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• CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer. [europepmc]
• Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma. [europepmc]
• Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy. [europepmc]
• Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. [europepmc]
• Macrophages as Key Drivers of Cancer Progression and Metastasis. [europepmc]
• Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression. [europepmc]
• Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial. [europepmc]
• The Immune Revolution: A Case for Priming, Not Checkpoint. [europepmc]
• Understanding the tumor immune microenvironment (TIME) for effective therapy. [europepmc]
• Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities. [europepmc]
• Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal. [europepmc]
• The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy. [europepmc]
• CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment. [europepmc]
• A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression. [europepmc]
• Host tissue determinants of tumour immunity. [europepmc]
• Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts. [europepmc]
• Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer. [europepmc]
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• CAR T cells in solid tumors: challenges and opportunities. [europepmc]
• Chemokines and the immune response to cancer. [europepmc]
• Multimodal Mapping of the Tumor and Peripheral Blood Immune Landscape in Human Pancreatic Cancer. [europepmc]
• The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. [europepmc]
• Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance. [europepmc]