Evidence That Pathogenic Transglutaminase 2 in Celiac Disease Derives From Enterocytes

2020/04/14 by Rasmus Iversen, Sunniva F. Amundsen, Liv Kleppa +4 · 25 citations
Medicine · Veterinary · #Celiac Disease Research and Management #Pancreatitis Pathology and Treatment #Animal health and immunology

paper · pdf · doi:10.1053/j.gastro.2020.04.018

Abstract

The enzyme transglutaminase 2 (TG2) plays a key role in celiac disease (CeD) pathogenesis through generation of immunogenic, deamidated gluten T-cell epitopes, and as a target of autoantibodies. The disorder is caused by a maladaptive immune response to cereal gluten proteins, and accumulating evidence suggest that interactions between gluten-specific T cells and TG2-specific B cells are important for driving the disease. A big remaining question is where in the body TG2, which is a cytosolic protein, encounters gluten and engages the immune system.

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• Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols. [europepmc]
• Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease. [europepmc]
• Propofol Suppresses Microglia Inflammation by Targeting TGM2/NF- κ B Signaling. [europepmc]
• Microbial Transglutaminase Is a Very Frequently Used Food Additive and Is a Potential Inducer of Autoimmune/Neurodegenerative Diseases. [europepmc]
• TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease. [europepmc]
• Changes in Non-Deamidated versus Deamidated Epitope Targeting and Disease Prediction during the Antibody Response to Gliadin and Transglutaminase of Infants at Risk for Celiac Disease. [europepmc]
• Antibody Responses to Transglutaminase 3 in Dermatitis Herpetiformis: Lessons from Celiac Disease. [europepmc]
• Features of ZED1227: The First-In-Class Tissue Transglutaminase Inhibitor Undergoing Clinical Evaluation for the Treatment of Celiac Disease. [europepmc]
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• Expression of transglutaminase 2 in human gut epithelial cells: Implications for coeliac disease. [europepmc]
• The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment. [europepmc]
• Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3. [europepmc]
• Unraveling the Immunopathological Landscape of Celiac Disease: A Comprehensive Review. [europepmc]
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• New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease. [europepmc]
• Enterocyte-Derived and Catalytically Active Transglutaminase 2 in the Gut Lumen of Mice: Implications for Celiac Disease. [europepmc]
• Immune cell dynamics and mechanisms of epithelial injury in celiac disease. [europepmc]
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• Transglutaminase 2 at the Interface of Gene Regulation and Antigen Processing in HLA-Restricted Immunity of Celiac Disease. [europepmc]

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