A Novel Role for the Dioxin Receptor in Fatty Acid Metabolism and Hepatic Steatosis

2010/03/18 by Jung Hoon Lee, Taira Wada, Maria Febbraio +5 · 28 citations
Environmental Science · Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Toxic Organic Pollutants Impact #Peroxisome Proliferator-Activated Receptors #Pharmacogenetics and Drug Metabolism

paper · pdf · doi:10.1053/j.gastro.2010.03.033

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• Deficiency of the aryl hydrocarbon receptor in intestinal epithelial cells, but not hepatocytes, ameliorates atherosclerosis development by sex-dependently targeting the lipid metabolism
• Aryl hydrocarbon receptor pharmacology—mechanisms, ligands, and therapeutic potential
• Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model
• Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis. [europepmc]
• Aryl hydrocarbon receptor deficiency enhances insulin sensitivity and reduces PPAR-α pathway activity in mice. [europepmc]
• Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers. [europepmc]
• Obesity is mediated by differential aryl hydrocarbon receptor signaling in mice fed a Western diet. [europepmc]
• Toxicant-associated steatohepatitis. [europepmc]
• Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice. [europepmc]
• Role of the aryl hydrocarbon receptor (AhR) in lung inflammation. [europepmc]
• Energy metabolism in the liver. [europepmc]
• Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents. [europepmc]
• Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21. [europepmc]
• Aryl hydrocarbon receptor deficiency protects mice from diet-induced adiposity and metabolic disorders through increased energy expenditure. [europepmc]
• Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice. [europepmc]
• The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals. [europepmc]
• Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model. [europepmc]
• Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. [europepmc]
• Endocrine Disruptors and Developmental Origins of Nonalcoholic Fatty Liver Disease. [europepmc]
• Triglyceride Metabolism in the Liver. [europepmc]
• Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. [europepmc]
• Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages. [europepmc]
• Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes. [europepmc]
• AhR activation defends gut barrier integrity against damage occurring in obesity. [europepmc]
• Drug Mimicry: Promiscuous Receptors PXR and AhR, and Microbial Metabolite Interactions in the Intestine. [europepmc]
• The aryl hydrocarbon receptor as a mediator of host-microbiota interplay. [europepmc]
• Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. [europepmc]
• The aryl hydrocarbon receptor in liver inflammation. [europepmc]