2011/05/23 by Vincent Calvez, Calvez, Vincent, Raymond J. Hawkins +5
Biochemistry, Genetics and Molecular Biology · Mathematics · #Analysis of PDEs (math.AP) #FOS: Mathematics #Gene Regulatory Network Analysis #Mathematical Biology Tumor Growth #Microtubule and mitosis dynamics
paper · pdf · doi:10.48550/arxiv.1105.4429
openalex publication_date 2011/05/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
In this work, we investigate the dynamics of a non-local model describing spontaneous cell polarisation. It consists in a drift-diffusion equation set in the half-space, with the coupling involving the trace value on the boundary. We characterize the following behaviours in the one-dimensional case: solutions are global if the mass is below the critical mass and they blow-up in finite time above the critical mass. The higher-dimensional case is also discussed. The results are reminiscent of the classical Keller-Segel system in double the dimension. In addition, in the one-dimensional case we prove quantitative convergence results using relative entropy techniques. This work is complemented with a more realistic model that takes into account dynamical exchange of molecular content at the boundary. In the one-dimensional case we prove that blow-up is prevented. Furthermore, density converges towards a non trivial stationary configuration.