O-LM interneurons: gatekeepers of pyramidal neuron activity in the hippocampus

2023/11/30 by Poll, Stefanie, Fuhrmann, Martin
#Animals #CA1 #E/I imbalance #Hippocampus #Interneurons: physiology #MeCP2 #Medicine and health #Mice #O-LM interneurons #Pyramidal Cells: physiology #Rett Syndrome #long-term memory impairment #somatostatin-expressing interneurons

paper · doi:10.60944/dzne-2022-00710

Abstract

A balanced and fine-tuned ratio of neuronal excitation and inhibition is a crucial prerequisite for information processing. In this issue of NEURON, He et al. reveal a causal link between reduced input to local somatostatin-expressing, MeCP2-negative O-LM interneurons in CA1 and long-term memory impairment in a mouse model of Rett syndrome.

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