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Diffusion-based Sinogram Interpolation for Limited Angle PET

2025/11/12 by Rüveyda Yilmaz, Yilmaz, Rüveyda, Julian Thull +5
Medicine · Computer Science · Mathematics · #Medical Imaging Techniques and Applications #Medical Image Segmentation Techniques #Markov Chains and Monte Carlo Methods

paper · pdf · doi:10.48550/arxiv.2511.09383

Abstract

Accurate PET imaging increasingly requires methods that support unconstrained detector layouts from walk-through designs to long-axial rings where gaps and open sides lead to severely undersampled sinograms. Instead of constraining the hardware to form complete cylinders, we propose treating the missing lines-of-responses as a learnable prior. Data-driven approaches, particularly generative models, offer a promising pathway to recover this missing information. In this work, we explore the use of conditional diffusion models to interpolate sparsely sampled sinograms, paving the way for novel, cost-efficient, and patient-friendly PET geometries in real clinical settings.

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