2024/08/08 by Joanne Aggett, Aggett, Joanne
Immunology and Microbiology · Medicine · #Galectins and Cancer Biology #Phagocytosis and Immune Regulation #Sarcoidosis and Beryllium Toxicity Research
paper · pdf · doi:10.24382/33b4-ax28
openalex publication_date 2024/08/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/01
The study of Nucleotide-Binding Oligomerization Domain (NOD) Proteins is a very \nnew area of immunology, with the gene for NOD2 having only been mapped in 2001 \n(Ogura et al 2001). It holds particular significance for those researching autoimmune \ndisorders such as Blau syndrome and Crohns Disease (CD), as it has been found \nthat a mutation in the NOD2 gene is present in a substantial proportion of CD \nsufferers, and having the mutation increases a person‟s susceptibility to developing \nthe disease later in life (Economou et al 2004). This review will look at the current \nresearch surrounding the NOD proteins and what products they form, and how this \ncan be used to further our knowledge of CD and how it can be managed. It will be \nspecifically looking into the effects that NOD proteins in macrophages have on the \nsecretion of various pro- and anti-inflammatory cytokines and how these can be \naugmented by the interaction of NOD protein signalling pathways with those of other \nmolecules in the cell.