Less is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization

2008/04/29 by Lubna Pal, Sangita Jindal, Barry R. Witt +1 · 25 citations
Medicine · #Ovarian function and disorders #Reproductive Biology and Fertility #Reproductive Health and Technologies

paper · pdf · doi:10.1016/j.fertnstert.2007.05.055

Citations

• High rate of aneuploidy in luteinized granulosa cells obtained from follicular fluid in women who underwent controlled ovarian hyperstimulation
• Follicle-Stimulating Hormone Affects Metaphase I Chromosome Alignment and Increases Aneuploidy in Mouse Oocytes Matured in Vitro1

Cited by

• Increased gonadotrophin stimulation does not improve IVF outcomes in patients with predicted poor ovarian reserve. [europepmc]
• The absorption and uptake of recombinant human follicle-stimulating hormone through vaginal subcutaneous injections--a pharmacokinetic study. [europepmc]
• Prolonged gonadotropin stimulation is associated with decreased ART success. [europepmc]
• Defining ovarian reserve to better understand ovarian aging. [europepmc]
• Milder is better? Advantages and disadvantages of "mild" ovarian stimulation for human in vitro fertilization. [europepmc]
• Does higher starting dose of FSH stimulation with letrozole improve fertility preservation outcomes in women with breast cancer? [europepmc]
• "Mild" vs. "long" protocol for controlled ovarian hyperstimulation in patients with expected poor ovarian responsiveness undergoing in vitro fertilization (IVF): a large prospective randomized trial. [europepmc]
• Prolonged gonadotropin stimulation for assisted reproductive technology cycles is associated with decreased pregnancy rates for all women except for women with polycystic ovary syndrome. [europepmc]
• Gonadotropin dose is negatively correlated with live birth rate: analysis of more than 650,000 assisted reproductive technology cycles. [europepmc]
• Using a mild stimulation protocol combined with clomiphene citrate and recombinant follicle-stimulating hormone to determine the optimal number of oocytes needed to achieve pregnancy and reduce the concerns of patients. [europepmc]
• Length of ovarian stimulation does not impact live birth rate in fresh donor oocyte cycles: a SART CORS study. [europepmc]
• Negative impact of high doses of follicle-stimulating hormone during superovulation on the ovulatory follicle function in small ovarian reserve dairy heifers†. [europepmc]
• FSH dose is negatively correlated with number of oocytes retrieved: analysis of a data set with ~650,000 ART cycles that previously identified an inverse relationship between FSH dose and live birth rate. [europepmc]
• Dose adjustment of follicle-stimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: a systematic review covering 10 years (2007-2017). [europepmc]
• Association Between the Ratio of Ovarian Stimulation Duration to Original Follicular Phase Length and In Vitro Fertilization Outcomes: A Novel Index to Optimise Clinical Trigger Time. [europepmc]
• High initial FSH dosage reduces the number of available cleavage-stage embryos in a GnRH-antagonist protocol: Real-world data of 8,772 IVF cycles from China. [europepmc]
• Knockout of Rlim Results in a Sex Ratio Shift toward Males but Superovulation Cannot Compensate for the Reduced Litter Size. [europepmc]
• Ovarian stimulation with excessive FSH doses causes cumulus cell and oocyte dysfunction in small ovarian reserve heifers. [europepmc]
• A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System. [europepmc]
• Follitropin delta combined with menotropin in patients at risk for poor ovarian response during in vitro fertilization cycles: a prospective controlled clinical study. [europepmc]
• Excessive Exogenous Gonadotropins and Genetic and Pregnancy Outcomes After Euploidy Embryo Transfer: A Secondary Analysis of a Randomized Clinical Trial. [europepmc]
• Optimizing oocyte yield utilizing a machine learning model for dose and trigger decisions, a multi-center, prospective study. [europepmc]
• Unraveling the Clinical FSH Conundrum: Insights From the Small Ovarian Reserve Heifer Model. [europepmc]
• The management of slow ovarian response in PCOS patients and its impact on clinical pregnancy outcomes. [europepmc]
• Effect of Prolonged Ovarian Stimulation (24 and 48 Hours) Compared to Conventional Duration on IVF/ICSI Outcomes: A Single-Blind Randomized Clinical Trial : Effect of Prolonged Ovarian Stimulation on IVF/ICSI. [europepmc]