Expression and function of interferon lambda receptor 1 variants

2024/10/22 by Laura A. Novotny, Eric G. Meissner · 3 citations
Immunology and Microbiology · Medicine · #Immune Response and Inflammation #interferon and immune responses #Cytokine Signaling Pathways and Interactions

paper · pdf · doi:10.1002/1873-3468.15041

Abstract

Lambda interferons (IFNLs) provide critical host defense against pathogens encountered at mucosal surfaces. In humans, IFNL signaling is regulated in part by low and cell-type restricted expression of the lambda interferon receptor 1 protein with expression restricted primarily to epithelial cells located at mucosal surfaces. This review will examine the evidence suggesting a role for IFNLR1 transcriptional variants in mediating cell responsiveness to IFNL ligand exposure and regulation of pathway activity.

Citations

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