Short‐time non‐enzymatic nitric oxide synthesis from L‐arginine and hydrogen peroxide induced by shock waves treatment

2002/05/14 by G. Gotte, Giovanni Gotte, E. Amelio +8 · 134 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Amino acid #Arginine #Biochemistry #Biology #Biophysics #Chemistry #Enzyme #Hemoglobin structure and function #Hydrogen peroxide #Internal medicine #Kinetics #Medicine #Nitric Oxide and Endothelin Effects #Nitric oxide #Organic chemistry #Oxide #Photoreceptor and optogenetics research #Physics #Shock (circulatory) #Shock wave

paper · pdf · doi:10.1016/s0014-5793(02)02807-7

published in FEBS Letters 520(1-3), 153-155 (Wiley)

openalex publication_date 2002/05/14 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/25

Abstract

The evidence that nitric oxide (NO) production is possible by a non-enzymatic pathway has already been shown under restrictive experimental conditions. Here we show that NO can non-enzymatically be formed with short-time kinetics (min), by 'bombing' with shock waves a solution containing 1 mM hydrogen peroxide and 10 mM L-arginine. This procedure is widening its medical application with surprisingly positive effects in tissue regeneration and our finding could be one of the first steps for the understanding of the biochemical responsible for these therapeutical effects.

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