Ethical and legal considerations of digital animal models: pioneering reduction and replacement

2025/10/01 by Germani, Federico, Werner, März Julian, Luciani, Alessandro +2
Veterinary · Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Animal testing and alternatives #Zebrafish Biomedical Research Applications #Immunotoxicology and immune responses

paper · doi:10.5167/uzh-279813

Abstract

The development of digital animal models represents a promising avenue for advancing the ethical principles of reduction and replacement in biomedical research. This paper discusses the potential of models built upon artificial intelligence (AI)-generated synthetic datasets simulating the characteristics and behaviors of model organisms, reducing reliance on live animals in research.

Related

• Harm to Nonhuman Animals from AI: a Systematic Account and Framework
• Ethical considerations regarding animal experimentation
• The Case for Animal-Friendly AI
• Artificial intelligence and machine learning in veterinary medicine: a regulatory perspective on current initiatives and future prospects
• The Importance of Animal Models in Biomedical Research: Current Insights and Applications