Biological interactions between polysaccharides and divalent cations: The egg‐box model

1973/05/15 by Gregor T. Grant, Edwin R. Morris, David A. Rees +3 · 34 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Polysaccharides and Plant Cell Walls #Polysaccharides Composition and Applications #Enzyme Production and Characterization

paper · pdf · doi:10.1016/0014-5793(73)80770-7

Abstract

We han, e shown that spedfic binding of divalent cations to a polysaechafide polyelectro]ym, leading firm cohesion between the chains, can cause characteristic effects ~n ~e c~rcutar diehroism spectrum which are understandabb in terms of modem theo~, [ l ]. For atginate, tiffs binding is a co-operative p,~otess that predominantly in~oNes consecuti~'e ~luronale residues. Some other systems ha~e now been inves,~igated in an attempt to formulate a general inSetpretafion of bio]ogics] phenomena of this type. T~e known streng~ and specificity of comp~exafion are explained m termg of an "'egg-box model" which ~s ,derN,ed from our measmemems, the known coordination geometries in mode] compounds, and the require-men~s roar ~ooperafivity.

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