Model of interaction of the IL‐1 receptor accessory protein IL‐1RAcP with the IL‐1β/IL‐1R_I complex

2001/06/14 by Rita Casadio, Elisabetta Frigimelica, Paola Bossù +5 · 18 citations
Immunology and Microbiology · #Immune Response and Inflammation #Immune Cell Function and Interaction #Toxin Mechanisms and Immunotoxins

paper · doi:10.1016/s0014-5793(01)02515-7

Abstract

A preliminary model has been calculated for the activating interaction of the interleukin 1 receptor (IL-1R) accessory protein IL-1RAcP with the ligand/receptor complex IL-1beta/IL-1R(I). First, IL-1RAcP was modeled on the crystal structure of IL-1R(I) bound to IL-1beta. Then, the IL-1RAcP model was docked using specific programs to the crystal structure of the IL-1beta/IL-1R(I) complex. Two types of models were predicted, with comparable probability. Experimental data obtained with the use of IL-1beta peptides and antibodies, and with mutated IL-1beta proteins, support the BACK model, in which IL-1RAcP establishes contacts with the back of IL-1R(I) wrapped around IL-1beta.

Citations

• PROCHECK: a program to check the stereochemical quality of protein structures
• Comparative Protein Modelling by Satisfaction of Spatial Restraints

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