The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS
2007/12/03 by Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota · 26 citations
Medicine · Neuroscience · #Adipokines, Inflammation, and Metabolic Diseases #Regulation of Appetite and Obesity #Adipose Tissue and Metabolism
paper · doi:10.1016/j.febslet.2007.11.070
Abstract
Adiponectin is an abundantly expressed adipokine in adipose tissue and has direct insulin sensitizing activity. A decrease in the circulating levels of adiponectin by interactions between genetic factors and environmental factors causing obesity has been shown to contribute to the development of insulin resistance, type 2 diabetes, metabolic syndrome and atherosclerosis. In addition to its insulin sensitizing actions, adiponectin has central actions in the regulation of energy homeostasis. Adiponectin enhances AMP-activated protein kinase activity in the arcuate hypothalamus via its receptor AdipoR1 to stimulate food intake and decreases energy expenditure. We propose a hypothesis on the physiological role of adiponectin: a starvation gene in the course of evolution by promoting fat storage on facing the loss of adiposity.
Cited by
- The inflammation highway: metabolism accelerates inflammatory traffic in obesity
- Brain regulation of appetite and satiety. [europepmc]
- Protective vascular and myocardial effects of adiponectin. [europepmc]
- Induction of chemokine expression by adiponectin in vitro is isoform dependent. [europepmc]
- Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. [europepmc]
- Infliximab therapy increases body fat mass in early rheumatoid arthritis independently of changes in disease activity and levels of leptin and adiponectin: a randomised study over 21 months. [europepmc]
- Globular adiponectin, acting via AdipoR1/APPL1, protects H9c2 cells from hypoxia/reoxygenation-induced apoptosis. [europepmc]
- Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance. [europepmc]
- Design and development of a peptide-based adiponectin receptor agonist for cancer treatment. [europepmc]
- Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans. [europepmc]
- Adiponectin action: a combination of endocrine and autocrine/paracrine effects. [europepmc]
- The inflammation highway: metabolism accelerates inflammatory traffic in obesity. [europepmc]
- Sphingolipid metabolism and obesity-induced inflammation. [europepmc]
- Novel targets of antifibrotic and anti-inflammatory treatment in CKD. [europepmc]
- Adipokines as drug targets in diabetes and underlying disturbances. [europepmc]
- The role of adipokines in the rapid antidepressant effects of ketamine. [europepmc]
- Hypothalamic AMPK as a Regulator of Energy Homeostasis. [europepmc]
- Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target. [europepmc]
- Mechanisms of obesity-induced metabolic and vascular dysfunctions. [europepmc]
- Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases. [europepmc]
- Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? [europepmc]
- Ceramides in Adipose Tissue. [europepmc]
- Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions. [europepmc]
- Adiponectin as a Potential Biomarker for Pregnancy Disorders. [europepmc]
- The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism. [europepmc]
- The Role of Adipokines in Health and Disease. [europepmc]
Related