Correlation of mRNA and protein in complex biological samples
2009/10/20 by Tobias Maier, Marc Güell, Luis Serrano +1 · 1,859 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Biochemistry #Biology #Chemistry #Computational biology #Correlation #Gene #Messenger RNA #Molecular Biology Techniques and Applications #Protein biosynthesis #Protein expression #Protein turnover #RNA #RNA Research and Splicing #RNA and protein synthesis mechanisms #Ribosome
paper · doi:10.1016/j.febslet.2009.10.036
published in FEBS Letters 583(24), 3966-3973 (Wiley)
openalex publication_date 2009/10/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Abstract
The correlation between mRNA and protein abundances in the cell has been reported to be notoriously poor. Recent technological advances in the quantitative analysis of mRNA and protein species in complex samples allow the detailed analysis of this pathway at the center of biological systems. We give an overview of available methods for the identification and quantification of free and ribosome-bound mRNA, protein abundances and individual protein turnover rates. We review available literature on the correlation of mRNA and protein abundances and discuss biological and technical parameters influencing the correlation of these central biological molecules.
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