The oligomeric conformation of peroxiredoxins links redox state to function

2009/05/21 by Sergio Barranco-Medina, Juan-José Lázaro, Karl-Josef Dietz +1 · 25 citations
Biochemistry, Genetics and Molecular Biology · #Redox biology and oxidative stress #Heat shock proteins research #Glutathione Transferases and Polymorphisms

paper · doi:10.1016/j.febslet.2009.05.029

Abstract

Protein-protein associations, i.e. formation of permanent or transient protein complexes, are essential for protein functionality and regulation within the cellular context. Peroxiredoxins (Prx) undergo major redox-dependent conformational changes and the dynamics are linked to functional switches. While a large number of investigations have addressed the principles and functions of Prx oligomerization, understanding of the diverse in vivo roles of this conserved redox-dependent feature of Prx is slowly emerging. The review summarizes studies on Prx oligomerization, its tight connection to the redox state, and the knowledge and hypotheses on its physiological function in the cell as peroxidase, chaperone, binding partner, enzyme activator and/or redox sensor.

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• Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin. [europepmc]
• Novel roles of peroxiredoxins in inflammation, cancer and innate immunity. [europepmc]
• Peroxiredoxins are conserved markers of circadian rhythms. [europepmc]
• Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. [europepmc]
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• Dissecting the integrative antioxidant and redox systems in plant mitochondria. Effect of stress and S-nitrosylation. [europepmc]
• Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer. [europepmc]
• Tuning of peroxiredoxin catalysis for various physiological roles. [europepmc]
• Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling. [europepmc]
• The role of peroxiredoxins in cancer. [europepmc]
• Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins. [europepmc]
• Peroxiredoxins in Cancer and Response to Radiation Therapies. [europepmc]
• Role of Cytosolic 2-Cys Prx1 and Prx2 in Redox Signaling. [europepmc]
• Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression. [europepmc]
• Cross-talk between redox signalling and protein aggregation. [europepmc]
• Real-time monitoring of peroxiredoxin oligomerization dynamics in living cells. [europepmc]
• Thioredoxin Network in Plant Mitochondria: Cysteine S-Posttranslational Modifications and Stress Conditions. [europepmc]
• Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities. [europepmc]

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