2007/09/24 by L. Imayavaramban, D. Dhayaparan, Devaraj Dhayaparan +1 · 3 citations
Neuroscience · Environmental Science · Agricultural and Biological Sciences · #Neurobiology and Insect Physiology Research #Physiological and biochemical adaptations #Aquaculture Nutrition and Growth
paper · doi:10.1016/j.febslet.2007.09.029
The present study was focused on the regulation of ecdysteroidogenesis in the Y-organ of Scylla serrata during molting cycle. A strong expression of molt-inhibiting hormone (MIH) and phosphorylation of ERK was predominantly observed in the postmolt and intermolt stages of Y-organs, whereas protein kinase C, steroidogenic acute regulatory protein (StAR) and cytochrome P450(scc) activity were exclusively seen in the premolt stages. Interestingly, inhibition of ERK phosphorylation by PD98059 in the early postmolt (A), middle postmolt (B) and intermolt (C) stages resulted in the prominent expression of PKC and StAR in the postmolt stages. This result indicates that phosphorylation of ERK is required for suppression of ecdysteroid biosynthesis with the involvement of protein kinase C, and StAR protein.