Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain

1994/04/04 by Koichi Ishiguro, Shunsuke Kobayashi, Akira Onion +6 · 15 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Alzheimer's disease research and treatments #Cancer-related Molecular Pathways #Microtubule and mitosis dynamics

paper · pdf · doi:10.1016/0014-5793(94)80501-6

Abstract

Tau protein kinase II (TPKII) was reported previously to be composed of a neuron-rich cdc2-related kinase (PSSALRE/cdk5) and 23 kDa subunit. Here we show that the 23 kDa subunit is a putative activator for the kinase activity. Amino acid sequence analysis revealed that the protein was novel and included a partial similarity of amino acids to a cyclin box important for the interaction with cdc2-related kinase. These results suggest that the 23 kDa subunit, but not cyclin, activates cdk5 in neuronal cells, which no longer exhibit cell cycling but are terminally differentiated cells.

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