Pharmacological inhibition of P2RX4 receptor as a potential therapeutic strategy to prevent intracranial aneurysm formation

2024/11/15 by Isao Ono, Masahiko Itani, Akihiro Okada +4
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · Psychology · #Adenosine and Purinergic Signaling #Aneurysm #Intracranial Aneurysms: Treatment and Complications #Medicine #Neurological Complications and Syndromes #Neuroscience #Psychology #Surgery

paper · doi:10.1016/j.expneurol.2024.115061

openalex publication_date 2024/11/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22

Citations

• PGE2‐EP2 signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF‐κB