Microglia in the TBI brain: The good, the bad, and the dysregulated

2015/09/03 by David J. Loane, Alok Kumar · 32 citations
Neuroscience · Immunology and Microbiology · Medicine · #Neuroinflammation and Neurodegeneration Mechanisms #Immune cells in cancer #Traumatic Brain Injury and Neurovascular Disturbances

paper · doi:10.1016/j.expneurol.2015.08.018

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• Mesenchymal stem cell-derived secretome in traumatic brain injury: Stage-specific paracrine mechanisms and translational challenges
• Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets
• Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury
• Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model
• TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism
• Extracellular vesicles combined with hyperbaric oxygen therapy as new strategies for the treatment of traumatic brain injury: A narrative review
• Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury
• Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage. [europepmc]
• Traumatic Axonal Injury: Mechanisms and Translational Opportunities. [europepmc]
• NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury. [europepmc]
• Anti-Inflammatory Activity of Natural Products. [europepmc]
• Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation. [europepmc]
• The far-reaching scope of neuroinflammation after traumatic brain injury. [europepmc]
• Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury. [europepmc]
• Microglia: Housekeeper of the Central Nervous System. [europepmc]
• Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases. [europepmc]
• Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines. [europepmc]
• Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury. [europepmc]
• Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift. [europepmc]
• Quantitative microglia analyses reveal diverse morphologic responses in the rat cortex after diffuse brain injury. [europepmc]
• Bidirectional Microglia-Neuron Communication in Health and Disease. [europepmc]
• A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury. [europepmc]
• Aberrant ER Stress Induced Neuronal-IFNβ Elicits White Matter Injury Due to Microglial Activation and T-Cell Infiltration after TBI. [europepmc]
• Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. [europepmc]
• Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits. [europepmc]
• Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury. [europepmc]
• The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target. [europepmc]
• Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis. [europepmc]
• Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury. [europepmc]
• Traumatic Brain Injury and Risk of Neurodegenerative Disorder. [europepmc]
• Traumatic Brain Injury: Mechanisms of Glial Response. [europepmc]
• Microglia and Neuroinflammation: Crucial Pathological Mechanisms in Traumatic Brain Injury-Induced Neurodegeneration. [europepmc]