Alpha adrenergic receptor signaling in the hypothalamic paraventricular nucleus is diminished by the chronic intermittent hypoxia model of sleep apnea

2020/10/23 by Gean Domingos-Souza, Diana Martinez, Diana Martínez +3 · 11 citations
Chemistry · Medicine · Neuroscience · #Adrenergic receptor #Biology #Brainstem #Catecholamine #Catecholaminergic #Catecholaminergic cell groups #Chemistry #Dopamine #Endocrinology #Hypothalamus #Hypoxia (environmental) #Internal medicine #Medicine #Neuropeptide #Neuroscience #Neuroscience of respiration and sleep #Norepinephrine #Nucleus #Obstructive Sleep Apnea Research #Orexin #Receptor #Sleep and Wakefulness Research

paper · doi:10.1016/j.expneurol.2020.113517

openalex publication_date 2020/10/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

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• The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition. [europepmc]
• Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia-induced peripheral chemoreflex responses. [europepmc]
• Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury. [europepmc]
• Chronic intermittent hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production. [europepmc]
• Oxytocin and corticotropin-releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia. [europepmc]
• Acetylome Analyses Provide New Insights into the Effect of Chronic Intermittent Hypoxia on Hypothalamus-Dependent Endocrine Metabolism Impairment. [europepmc]
• Norepinephrine triggers glutamatergic long-term potentiation in hypothalamic paraventricular nucleus magnocellular neuroendocrine cells through postsynaptic β1-AR/PKA signaling pathway in vitro in rats. [europepmc]
• Deficiency of neuronal LGR4 increases energy expenditure and inhibits food intake via hypothalamic leptin signaling. [europepmc]
• The Role of Oxytocin Neurons in the Paraventricular Nucleus in Chronic-Sleep-Deprivation-Mediated Abnormal Cardiovascular Responses. [europepmc]
• Paraventricular nucleus neurons: important regulators of respiratory movement in mice with chronic intermittent hypoxia. [europepmc]
• PVN mechanisms in OSA comorbidities: from intermittent hypoxia-stress to therapy. [europepmc]