Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS

2006/06/23 by Wenqian Li, W LI, Jacques Penderis +7 · 26 citations
Neuroscience · #Neurogenesis and neuroplasticity mechanisms #Neuroinflammation and Neurodegeneration Mechanisms #Stress Responses and Cortisol

paper · doi:10.1016/j.expneurol.2006.05.012

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• Increases in size and myelination of the rat corpus callosum during adulthood are maintained into old age. [europepmc]
• Remyelination in multiple sclerosis. [europepmc]
• Interplay of hormones and p53 in modulating gender dimorphism of subventricular zone cell number. [europepmc]
• Sexual dimorphism of oligodendrocytes is mediated by differential regulation of signaling pathways. [europepmc]
• Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. [europepmc]
• Sex effects of interleukin-6 deficiency on neuroinflammation in aged C57Bl/6 mice. [europepmc]
• Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey. [europepmc]
• Developmental PCB exposure induces hypothyroxinemia and sex-specific effects on cerebellum glial protein levels in rats. [europepmc]
• Macrophages counteract demyelination in a mouse model of globoid cell leukodystrophy. [europepmc]
• Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis. [europepmc]
• Sural nerve involvement in experimental hypertension: morphology and morphometry in male and female normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). [europepmc]
• Polydendrocytes in development and myelin repair. [europepmc]
• Schwann cells generated from neonatal skin-derived precursors or neonatal peripheral nerve improve functional recovery after acute transplantation into the partially injured cervical spinal cord of the rat. [europepmc]
• Remyelination Therapy in Multiple Sclerosis. [europepmc]
• Sensory and Motor Conduction Velocity in Spontaneously Hypertensive Rats: Sex and Aging Investigation. [europepmc]
• Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse. [europepmc]
• Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function. [europepmc]
• Neuronal androgen receptor is required for activity dependent enhancement of peripheral nerve regeneration. [europepmc]
• Sex disparity of cerebral white matter hyperintensity in the hypertensive elderly: The Shanghai Changfeng study. [europepmc]
• Sexual Dimorphism in Lesion Size and Sensorimotor Responses Following Spinal Cord Injury. [europepmc]
• Potential biological contributers to the sex difference in multiple sclerosis progression. [europepmc]
• Remyelination in the Central Nervous System. [europepmc]
• Aging differentially alters the transcriptome and landscape of chromatin accessibility in the male and female mouse hippocampus. [europepmc]
• Influencing factors and repair advancements in rodent models of peripheral nerve regeneration. [europepmc]
• Influence of biological sex on neuroinflammatory dynamics in the aging brain. [europepmc]