Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window

2016/05/28 by Bin Chen, Bo Feng, Yangshun Tang +5 · 16 citations
Neuroscience · Medicine · Biochemistry, Genetics and Molecular Biology · #Neuroscience and Neuropharmacology Research #Epilepsy research and treatment #Lipid Membrane Structure and Behavior

paper · doi:10.1016/j.expneurol.2016.05.034

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• Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis. [europepmc]
• Neonatal Febrile Seizures in Rats Induce Long-Term Region-Specific Alterations in the Glutamatergic System of Hippocampal-Prefrontal Circuits and Lead to Behavioral Deficits. [europepmc]
• TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to prolonged FS-induced epileptogenesis. [europepmc]