Corneal nerves and their role in dry eye pathophysiology

2022/07/16 by Alexia Vereertbrugghen, Jeremías G. Galletti · 25 citations
Agricultural and Biological Sciences · Medicine · Neuroscience · Pharmacology, Toxicology and Pharmaceutics · #Advancements in Transdermal Drug Delivery #Anatomy #Anesthesia #Bee Products Chemical Analysis #Biology #Cornea #Corneal Diseases #Corneal reflex #Medicine #Neuroscience #Ocular Surface and Contact Lens #Ophthalmology #Pathology #Pathophysiology #Reflex

paper · doi:10.1016/j.exer.2022.109191

openalex publication_date 2022/07/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Cited by

• Change Patterns in Corneal Intrinsic Aberrations and Nerve Density after Cataract Surgery in Patients with Dry Eye Disease. [europepmc]
• A, B, C's of Trk Receptors and Their Ligands in Ocular Repair. [europepmc]
• An ocular Th1 immune response promotes corneal nerve damage independently of the development of corneal epitheliopathy. [europepmc]
• Collagen mimetic peptide repair of the corneal nerve bed in a mouse model of dry eye disease. [europepmc]
• Relationship between ocular surface pain and corneal nerve loss in dry eye diabetics: a cross-sectional study in Shenyang, China. [europepmc]
• A Phase 2 Trial to Test Safety and Efficacy of ST-100, a Unique Collagen Mimetic Peptide Ophthalmic Solution for Dry Eye Disease. [europepmc]
• Transient Receptor Potential Vanilloid-1 Channels Facilitate Axonal Degeneration of Corneal Sensory Nerves in Dry Eye. [europepmc]
• The miR-183/96/182 cluster regulates sensory innervation, resident myeloid cells and functions of the cornea through cell type-specific target genes. [europepmc]
• Recent United States Developments in the Pharmacological Treatment of Dry Eye Disease. [europepmc]
• Greater exposure to PM 2.5 and PM 10 was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study. [europepmc]
• Segmentation and multiparametric evaluation of corneal whorl-like nerves for in vivo confocal microscopy images in dry eye disease. [europepmc]
• CD4 + T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous-deficient dry eye model. [europepmc]
• Non-contact confocal calcium imaging of in vivo murine corneal nerves. [europepmc]
• Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients. [europepmc]
• Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease: An In Vivo Confocal Microscopy Study. [europepmc]
• The Prevalence of Corneal Sensitivity Loss in Patients with and without Dry Eye Disease. [europepmc]
• Correlation among ocular surface changes and systemic hematologic indexes and disease activity in primary Sjögren's syndrome: a cross-sectional study. [europepmc]
• Tear deficiency transforms spatial distribution of corneal calcitonin gene-related peptide-positive nerves in rats. [europepmc]
• Evaluation of the relationship between dry eye syndrome severity and corneal sensitivity. [europepmc]
• Spheroid assembly of mesenchymal stem cells enhances secretome-mediated corneal reinnervation and epithelial repair in a mouse model of experimental dry eye. [europepmc]
• Clinical Applications of Artificial Intelligence in Corneal Diseases. [europepmc]
• Baicalin nano-micelles for dry eye disease: LC-MS/MS method validation, pharmacokinetics and pharmacodynamics in preclinical models. [europepmc]
• Aptamer-Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies. [europepmc]
• Pathological mechanisms of Sjögren's disease-related dry eye: from multiglandular dysfunction to ocular surface inflammation. [europepmc]
• Modulation of corneal sensory processing and pain responses by dry eye and corneal wounding. [europepmc]