The pathophysiology of Fuchs' endothelial dystrophy – A review of molecular and cellular insights

2014/11/01 by Jie Zhang, Dipika V. Patel · 26 citations
Medicine · #Corneal surgery and disorders #Glaucoma and retinal disorders #Corneal Surgery and Treatments

paper · doi:10.1016/j.exer.2014.10.023

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• Biomechanical relationships between the corneal endothelium and Descemet's membrane
• Fuchs Endothelial Corneal Dystrophy: Strong Association with rs613872 Not Paralleled by Changes in Corneal Endothelial TCF4 mRNA Level. [europepmc]
• Wound-Induced Polyploidization: Regulation by Hippo and JNK Signaling and Conservation in Mammals. [europepmc]
• Biomechanical relationships between the corneal endothelium and Descemet's membrane. [europepmc]
• Patients With Dry Eye Disease and Low Subbasal Nerve Density Are at High Risk for Accelerated Corneal Endothelial Cell Loss. [europepmc]
• Corneal Endothelial Cell Loss 3 Years After Successful Descemet Stripping Automated Endothelial Keratoplasty in the Cornea Preservation Time Study: A Randomized Clinical Trial. [europepmc]
• Pathological molecular mechanism of symptomatic late-onset Fuchs endothelial corneal dystrophy by bioinformatic analysis. [europepmc]
• Basement membranes in the cornea and other organs that commonly develop fibrosis. [europepmc]
• Capabilities of Gabor-domain optical coherence microscopy for the assessment of corneal disease. [europepmc]
• Imaging the Corneal Endothelium in Fuchs Corneal Endothelial Dystrophy. [europepmc]
• Corneal Hydration Control during Ex Vivo Experimentation Using Poloxamers. [europepmc]
• Regional variability in corneal endothelial cell density between guttae and non-guttae areas in Fuchs endothelial corneal dystrophy. [europepmc]
• Diagnosis and Management of Pseudoguttata: A Literature Review. [europepmc]
• Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis. [europepmc]
• Peripheral-to-central ratio of Guttae: validity and reliability of an objective method to characterize severity of Fuchs endothelial corneal dystrophy. [europepmc]
• The Sociodemographic and Risk Factors for Fuchs' Endothelial Dystrophy: A Nationwide, Matched Case-Control Study in Taiwan. [europepmc]
• Identification of novel therapeutic targets for Fuchs' endothelial corneal dystrophy based on gene bioinformatics analysis. [europepmc]
• Fuchs endothelial corneal dystrophy: current perspectives on diagnostic pathology and genetics-Bowman Club Lecture. [europepmc]
• Advanced Anterior Eye Segment Imaging for Ichthyosis. [europepmc]
• A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation. [europepmc]
• Constructing networks for comparison of collagen types. [europepmc]
• Fuchs' Endothelial Corneal Dystrophy evaluation using a high-resolution wavefront sensor. [europepmc]
• Five Year Review of All Examined Corneal Tissue in a Tertiary Eye Care Center: Demographics and Surgical Indications. [europepmc]
• Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics. [europepmc]
• Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy. [europepmc]
• Generation of FECD Phenotypes in the Mouse Cornea by UVA Exposure and Surgical Removal of its Corneal Endothelial Layer. [europepmc]