Complement Activation and Inflammatory Processes in Drusen Formation and Age Related Macular Degeneration

2001/12/01 by Lincoln V Johnson, Lincoln V. Johnson, William P. Leitner +5 · 26 citations
Medicine · #Retinal Diseases and Treatments #Retinal Imaging and Analysis #Glaucoma and retinal disorders

paper · doi:10.1006/exer.2001.1094

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• Complement factor H polymorphism in age-related macular degeneration. [europepmc]
• A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. [europepmc]
• The role of inflammation in the pathogenesis of age-related macular degeneration. [europepmc]
• Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. [europepmc]
• Age-related macular degeneration--emerging pathogenetic and therapeutic concepts. [europepmc]
• Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. [europepmc]
• Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy. [europepmc]
• Molecular pathology of age-related macular degeneration. [europepmc]
• Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins. [europepmc]
• Soluble and mature amyloid fibrils in drusen deposits. [europepmc]
• The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. [europepmc]
• Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. [europepmc]
• Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex. [europepmc]
• Mechanisms of age-related macular degeneration. [europepmc]
• Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration. [europepmc]
• Nature and nurture- genes and environment- predict onset and progression of macular degeneration. [europepmc]
• Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. [europepmc]
• Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases. [europepmc]
• Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration. [europepmc]
• Inflammatory biomarkers in osteoarthritis. [europepmc]
• Inflammation and its role in age-related macular degeneration. [europepmc]
• The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. [europepmc]
• Complement factor H in AMD: Bridging genetic associations and pathobiology. [europepmc]
• Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models. [europepmc]
• The Role of Inflammation in Age-Related Macular Degeneration. [europepmc]