Diabetes Reduces Glutamate Oxidation and Glutamine Synthesis in the Retina

2000/06/01 by Erich Lieth, Kathryn F. LaNoue, Kathryn F LaNoue +3 · 178 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Amino acid #Biochemistry #Biology #Chemistry #Diabetes mellitus #Endocrinology #Glutamate dehydrogenase #Glutamate receptor #Glutamine #Glutamine synthetase #Internal medicine #Medicine #Neuroscience and Neuropharmacology Research #Photoreceptor and optogenetics research #Retinal Development and Disorders

paper · doi:10.1006/exer.2000.0840

published in Experimental Eye Research 70(6), 723-730 (Elsevier BV)

openalex publication_date 2000/06/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28

Citations

• Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group.
• Müller cell changes in human diabetic retinopathy.

Cited by

• Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications
• Diabetic Retinopathy
• Role of adenosine in diabetic retinopathy. [europepmc]
• Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications. [europepmc]
• Astrocytic energetics during excitatory neurotransmission: What are contributions of glutamate oxidation and glycolysis? [europepmc]
• Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment. [europepmc]
• Primary retinal cultures as a tool for modeling diabetic retinopathy: an overview. [europepmc]
• Neuroprotection as a Therapeutic Target for Diabetic Retinopathy. [europepmc]
• Neuroretinal Apoptosis as a Vascular Dysfunction in Diabetic Patients. [europepmc]
• The neurovascular unit and the pathophysiologic basis of diabetic retinopathy. [europepmc]
• Early inner retinal thinning and cardiovascular autonomic dysfunction in type 2 diabetes. [europepmc]
• Nanoparticle-Mediated Delivery of Neuroprotective Substances for the Treatment of Diabetic Retinopathy. [europepmc]
• E2f1 mediates high glucose-induced neuronal death in cultured mouse retinal explants. [europepmc]
• Müller cells and diabetic retinopathy. [europepmc]
• The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration. [europepmc]
• Plasma glutamine and glutamic acid are potential biomarkers for predicting diabetic retinopathy. [europepmc]
• Retinal Neurodegeneration as an Early Manifestation of Diabetic Eye Disease and Potential Neuroprotective Therapies. [europepmc]
• High Glucose-Induced TRPC6 Channel Activation Decreases Glutamate Uptake in Rat Retinal Müller Cells. [europepmc]
• Treatment of diabetic retinopathy through neuropeptide Y-mediated enhancement of neurovascular microenvironment. [europepmc]
• Proinflammatory cytokines trigger biochemical and neurochemical changes in mouse retinal explants exposed to hyperglycemic conditions. [europepmc]
• Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. [europepmc]
• Metabolic Dysregulation and Neurovascular Dysfunction in Diabetic Retinopathy. [europepmc]
• Contribution of Müller Cells in the Diabetic Retinopathy Development: Focus on Oxidative Stress and Inflammation. [europepmc]
• High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis. [europepmc]
• Serum Untargeted Metabolomics Reveal Potential Biomarkers of Progression of Diabetic Retinopathy in Asians. [europepmc]
• Interpretable machine learning-derived nomogram model for early detection of diabetic retinopathy in type 2 diabetes mellitus: a widely targeted metabolomics study. [europepmc]
• The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice. [europepmc]