Paracrine HGF/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP/HIF-1α

2018/07/26 by Bin Yan, Zhengdong Jiang, Liang Cheng +9 · 26 citations
Biochemistry, Genetics and Molecular Biology · #Hippo pathway signaling and YAP/TAZ #Cancer, Hypoxia, and Metabolism #Fibroblast Growth Factor Research

paper · doi:10.1016/j.yexcr.2018.07.041

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• MET alterations are enriched in lung adenocarcinoma brain metastases, defining a distinct biologic subtype
• TAMing pancreatic cancer: combat with a double edged sword. [europepmc]
• The enhancement of glycolysis regulates pancreatic cancer metastasis. [europepmc]
• Therapeutic Strategies Targeting Cancer Stem Cells and Their Microenvironment. [europepmc]
• Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance. [europepmc]
• Hippo-Yap/Taz signaling: Complex network interactions and impact in epithelial cell behavior. [europepmc]
• Metabolism of pancreatic cancer: paving the way to better anticancer strategies. [europepmc]
• Resveratrol Ameliorates the Malignant Progression of Pancreatic Cancer by Inhibiting Hypoxia-induced Pancreatic Stellate Cell Activation. [europepmc]
• Positive feedback in Cav-1-ROS signalling in PSCs mediates metabolic coupling between PSCs and tumour cells. [europepmc]
• Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding motif (TAZ): a nexus between hypoxia and cancer. [europepmc]
• Hippo Signaling Pathway as a Central Mediator of Receptors Tyrosine Kinases (RTKs) in Tumorigenesis. [europepmc]
• Metabolic reprograming of tumor-associated macrophages. [europepmc]
• Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition. [europepmc]
• The value of a metabolic reprogramming-related gene signature for pancreatic adenocarcinoma prognosis prediction. [europepmc]
• NEK1 Phosphorylation of YAP Promotes Its Stabilization and Transcriptional Output. [europepmc]
• The Glycolytic Pathway as a Target for Novel Onco-Immunology Therapies in Pancreatic Cancer. [europepmc]
• The PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions. [europepmc]
• The YAP/HIF-1α/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation. [europepmc]
• The metabolic flexibility of quiescent CSC: implications for chemotherapy resistance. [europepmc]
• Dependence receptors: new targets for cancer therapy. [europepmc]
• The Role of Cancer-Associated Fibroblast as a Dynamic Player in Mediating Cancer Stemness in the Tumor Microenvironment. [europepmc]
• Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma. [europepmc]
• Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer. [europepmc]
• Cancer-associated fibroblasts: The chief architect in the tumor microenvironment. [europepmc]
• Cancer Stem Cells in Pancreatic Ductal Adenocarcinoma. [europepmc]
• Pancreatic cancer stemness: dynamic status in malignant progression. [europepmc]