Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells

1986/02/01 by Denis Salomon, Paolo Meda · 27 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Pancreatic function and diabetes #Diabetes and associated disorders #Diabetes Management and Research

paper · doi:10.1016/0014-4827(86)90354-x

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• Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells
• Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity
• Single pancreatic beta cells co-express multiple islet hormone genes in mice. [europepmc]
• Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy. [europepmc]
• Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells. [europepmc]
• Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes. [europepmc]
• Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell. [europepmc]
• β-cell dedifferentiation in diabetes is important, but what is it? [europepmc]
• Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics. [europepmc]
• Beta cell connectivity in pancreatic islets: a type 2 diabetes target? [europepmc]
• MiRNAs in β-Cell Development, Identity, and Disease. [europepmc]
• β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. [europepmc]
• Evidence for Loss in Identity, De-Differentiation, and Trans -Differentiation of Islet β-Cells in Type 2 Diabetes. [europepmc]
• Beta cell heterogeneity: an evolving concept. [europepmc]
• The role of beta cell heterogeneity in islet function and insulin release. [europepmc]
• Single-Cell RNA-Seq of the Pancreatic Islets--a Promise Not yet Fulfilled? [europepmc]
• Heterogeneity of the Human Pancreatic Islet. [europepmc]
• Intact pancreatic islets and dispersed beta-cells both generate intracellular calcium oscillations but differ in their responsiveness to glucose. [europepmc]
• Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes. [europepmc]
• Functional changes in beta cells during ageing and senescence. [europepmc]
• PDX1 LOW MAFA LOW β-cells contribute to islet function and insulin release. [europepmc]
• The physiological role of β-cell heterogeneity in pancreatic islet function. [europepmc]
• Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis. [europepmc]
• Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response. [europepmc]
• A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. [europepmc]
• Epigenetic dosage identifies two major and functionally distinct β cell subtypes. [europepmc]
• Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A. [europepmc]