LRRK2 regulates synaptic vesicle endocytosis

2008/03/13 by Narae Shin, Hyerhan Jeong, Jungsun Kwon +14 · 27 citations
Medicine · Biochemistry, Genetics and Molecular Biology · Neuroscience · #Parkinson's Disease Mechanisms and Treatments #Cellular transport and secretion #Genetic Neurodegenerative Diseases

paper · doi:10.1016/j.yexcr.2008.02.015

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• Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson’s disease
• The Effect of p.G2019S Mutation in the LRRK2 Gene on the Activity of Lysosomal Hydrolases and the Clinical Features of Parkinson's Disease Associated with p.N370S Mutation in the GBA1 Gene
• Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation. [europepmc]
• Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. [europepmc]
• LRRK2 is involved in the IFN-gamma response and host response to pathogens. [europepmc]
• LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. [europepmc]
• LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. [europepmc]
• LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice. [europepmc]
• Dopamine release in the basal ganglia. [europepmc]
• Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. [europepmc]
• G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization. [europepmc]
• The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway. [europepmc]
• Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics. [europepmc]
• LRRK2 and neuroinflammation: partners in crime in Parkinson's disease? [europepmc]
• Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition. [europepmc]
• Cellular processes associated with LRRK2 function and dysfunction. [europepmc]
• Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students. [europepmc]
• Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation. [europepmc]
• LRRK2 at the interface of autophagosomes, endosomes and lysosomes. [europepmc]
• Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons. [europepmc]
• Rab GTPases and Membrane Trafficking in Neurodegeneration. [europepmc]
• LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation. [europepmc]
• Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models. [europepmc]
• Emerging roles of extracellular vesicles in neurodegenerative disorders. [europepmc]
• Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals? [europepmc]
• LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same. [europepmc]
• Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. [europepmc]