TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling

2007/09/19 by Carla Cicchini, Ilaria Laudadio, Franca Citarella +6 · 27 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Cancer Cells and Metastasis #Wnt/β-catenin signaling in development and cancer #Hippo pathway signaling and YAP/TAZ

paper · pdf · doi:10.1016/j.yexcr.2007.09.005

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• The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors. [europepmc]
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• Targeting lipid metabolism to overcome EMT-associated drug resistance via integrin β3/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery. [europepmc]
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