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Epidemiology-Aware Neural ODE with Continuous Disease Transmission Graph

2024/09/28 by Guancheng Wan, Wan, Guancheng, Zewen Liu +7 · 2 citations
Computer Science · #Artificial Intelligence (cs.AI) #FOS: Computer and information sciences #Machine Learning (cs.LG) #Social and Information Networks (cs.SI) #Statistical and Computational Modeling

paper · pdf · doi:10.48550/arxiv.2410.00049

openalex publication_date 2024/09/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Effective epidemic forecasting is critical for public health strategies and efficient medical resource allocation, especially in the face of rapidly spreading infectious diseases. However, existing deep-learning methods often overlook the dynamic nature of epidemics and fail to account for the specific mechanisms of disease transmission. In response to these challenges, we introduce an innovative end-to-end framework called Epidemiology-Aware Neural ODE with Continuous Disease Transmission Graph (EARTH) in this paper. To learn continuous and regional disease transmission patterns, we first propose EANO, which seamlessly integrates the neural ODE approach with the epidemic mechanism, considering the complex spatial spread process during epidemic evolution. Additionally, we introduce GLTG to model global infection trends and leverage these signals to guide local transmission dynamically. To accommodate both the global coherence of epidemic trends and the local nuances of epidemic transmission patterns, we build a cross-attention approach to fuse the most meaningful information for forecasting. Through the smooth synergy of both components, EARTH offers a more robust and flexible approach to understanding and predicting the spread of infectious diseases. Extensive experiments show EARTH superior performance in forecasting real-world epidemics compared to state-of-the-art methods. The code will be available at https://github.com/Emory-Melody/EpiLearn.

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