2017/05/26 by G. Campi, Gaetano Campi, Campi, G. +14
Biochemistry, Genetics and Molecular Biology · #Biomolecules (q-bio.BM) #Diffusion and Search Dynamics #FOS: Biological sciences #Lipid Membrane Structure and Behavior #Neurons and Cognition (q-bio.NC) #RNA Research and Splicing #q-bio.BM #q-bio.NC
paper · pdf · doi:10.48550/arxiv.1705.09730
7 pages, 1 figure, International Conference Superstripes 2017, Ischia (Italy) June, 4-10 2017
openalex publication_date 2017/05/26 · arxiv created 2017/10/26 · arxiv updated 2017/10/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The ultrastructure fluctuations and complex dynamics of the multi-layered membrane structure of myelin are fundamental for understanding and control its formation process and its degeneration and repair in neurological diseases such as multiple sclerosis (MS). Myelin is considered a liquid-crystal but information are confined to its average structure due to limitations of the available standard techniques. To overcome this limitation in this work we have used Scanning micro X-ray Diffraction (SμXRD) which is a unique non-invasive probe of both k-space and real space allowing to visualize disorder in myelin with high spatial resolution in real space. We have used this method to examine the myelin sheath in the sciatic nerve of Xenopus laevis. Our results open could open new venues for understanding formation and degradation of myelin.