2016/03/11 by Chris Barrett, Barrett, Christopher L., Thomas J. X. Li +3
Biochemistry, Genetics and Molecular Biology · Medicine · #05A16 #92E10 #Bacterial Genetics and Biotechnology #Biomolecules (q-bio.BM) #Combinatorics (math.CO) #DNA and Nucleic Acid Chemistry #FOS: Biological sciences #FOS: Mathematics #Monoclonal and Polyclonal Antibodies Research #Quantitative Methods (q-bio.QM) #RNA and protein synthesis mechanisms
paper · pdf · doi:10.48550/arxiv.1603.03653
openalex publication_date 2016/03/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Given a random RNA secondary structure, S, we study RNA sequences having fixed ratios of nuclotides that are compatible with S. We perform this analysis for RNA secondary structures subject to various base pairing rules and minimum arc- and stack-length restrictions. Our main result reads as follows: in the simplex of the nucleotide ratios there exists a convex region in which, in the limit of long sequences, a random structure a.a.s.~has compatible sequence with these ratios and outside of which a.a.s.~a random structure has no such compatible sequence. We localize this region for RNA secondary structures subject to various base pairing rules and minimum arc- and stack-length restrictions. In particular, for \bf GC-sequences having a ratio of \bf G nucleotides smaller than 1/3, a random RNA secondary structure without any minimum arc- and stack-length restrictions has a.a.s.~no such compatible sequence. For sequences having a ratio of \bf G nucleotides larger than 1/3, a random RNA secondary structure has a.a.s. such compatible sequences. We discuss our results in the context of various families of RNA structures.