2025/11/11 by Djin‐Ye Oh, Martin Hölzer, Daniela Börnigen +26 · 2 voices · 1 citation
Mathematics · Medicine · #COVID-19 epidemiological studies #Context (archaeology) #Coronavirus disease 2019 (COVID-19) #Pandemic #Perspective (graphical) #Public health #Public health policy #Public health surveillance #SARS-CoV-2 and COVID-19 Research #SARS-CoV-2 detection and testing #Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
paper · doi:10.1038/s43856-025-01093-1
published in Communications Medicine 5(1), 468 (Nature Portfolio)
openalex publication_date 2025/11/11 · openalex created_date 2025/11/14 · openalex updated_date 2026/07/29
This review summarizes key virological parameters of SARS-CoV-2, the clinical spectrum of COVID-19, antiviral options, resistance, and the evolution of SARS-CoV-2 during the first four years of the pandemic. It draws on evidence that has been continuously updated throughout the pandemic by the interdisciplinary working group 'SARS-CoV-2 Diagnostics and Evolution' at Robert Koch Institute (RKI), Germany's national public health institute. We describe basic SARS-CoV-2 characteristics and highlight notable virus variants from 2020 to mid-2023. During this period, the nationwide collection of SARS-CoV-2 genomes provided a substantial resource for monitoring viral lineage frequencies and mutations. We summarize this dataset to underscore the importance of virological surveillance in the context of public health and pandemic preparedness.