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Substrate Stiffness Changes Cell Rolling and Adhesion over L-selectin Coated Surface in a Viscous Shear Flow

2019/09/27 by Maryam Bagheri, Bagheri, Maryam, Mohammad Reza Azmoodeh +1
Medicine · #Biological Physics (physics.bio-ph) #Blood properties and coagulation #Cell Adhesion Molecules Research #FOS: Physical sciences #Platelet Disorders and Treatments

paper · pdf · doi:10.48550/arxiv.1910.00002

openalex publication_date 2019/09/27 · openalex created_date 2019/10/10 · openalex updated_date 2026/07/28

Abstract

Understanding the rolling and adhesion behavior of a cell on the vascular surface under viscous shear flow is important to better understand many biological processes. One of the important examples is the adhesion of the leukocytes onto sites of an inflammation. Recently, researchers have started to investigate the effects of surface rigidity on the cell rolling and adhesion. Inspired by recent studies, we employed Adhesive dynamics to investigate effects of substrate rigidity on a rolling cell in a hydrodynamic flow.

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