Serotonin and drug reward: focus on 5-HT2C receptors

2003/10/28 by Guy A Higgins, Guy A. Higgins, Paul J Fletcher +1 · 26 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Psychology · #5-HT receptor #5-HT2C receptor #Addiction #Biology #Drug #Drugs of abuse #Genetics #Neuroscience #Neurotransmitter Receptor Influence on Behavior #Pharmacology #Psychology #Receptor #Receptor Mechanisms and Signaling #Reward system #Serotonin

paper · doi:10.1016/j.ejphar.2003.08.102

openalex publication_date 2003/10/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/26

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• Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. [europepmc]
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• The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats. [europepmc]
• Role(s) of the 5-HT2C receptor in the development of maximal dentate activation in the hippocampus of anesthetized rats. [europepmc]
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• Effect of the 5-HT 2C Receptor Agonist WAY-163909 on Serotonin and Dopamine Metabolism across the Rat Brain: A Quantitative and Qualitative Neurochemical Study. [europepmc]
• Biphasic reward effects are characteristic of both lorcaserin and drugs of abuse: implications for treatment of substance use disorders. [europepmc]