Macrophage M1/M2 polarization

2020/03/29 by Chen Yunna, Hu Mengru, Mengru Hu +3 · 2,447 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · Medicine · #Biochemistry #Biology #Cancer research #Cancer, Stress, Anesthesia, and Immune Response #Cell biology #Chemistry #Drug #Function (biology) #Histone Deacetylase Inhibitors Research #Immune cells in cancer #Immunology #In vitro #Inflammation #Macrophage #Macrophage polarization #Macrophage-activating factor #Nanocarriers #Phagocytosis #Pharmacology #Signal transduction

paper · doi:10.1016/j.ejphar.2020.173090

published in European Journal of Pharmacology 877, 173090 (Elsevier BV)

openalex publication_date 2020/03/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Cited by

• RvE1/ChemR23 facilitates hematoma clearance and promotes M2 polarization of macrophages/microglia in intracerebral hemorrhage
• Targeting the adenosinergic axis in cancer immunotherapy: Insights into A2A and A2B receptors and novel clinical combination strategies
• Loss of ATF3 exacerbates pulmonary fibrosis via enhanced neutrophil recruitment and profibrotic macrophage polarization
• Resolvin D2 attenuates LPS ‐induced macrophage exhaustion
• LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype
• Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment
• The Activation of Hippocampal Microglial Cells and Their Role in the Regulation of Pain
• Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation
• Pulchinenoside B4 attenuates gouty arthritis by regulating NLRP3 inflammasome and macrophage polarization: a transcriptomics-based analysis
• Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications
• Ionizing radiation leads to exosome secretion in macrophages through MYC-mediated pathways
• The Multifaceted Role of Osteopontin in Modulating the Tumor Microenvironment
• Transcriptomics profiles in intestinal sulfide overproduction, small intestinal bacterial overgrowth, and intestinal methanogen overgrowth
• Lysine Acetyltransferase 6 in Health and Disease
• Single-Injection Multi-Omics Analysis by Direct Infusion Mass Spectrometry
• Intrarenal renin–angiotensin system inactivation ameliorates tubulopathy via attenuation of mitochondrial oxidative stress, dysfunction and senescence in diabetes
• Mapping the immune cells of the testis: Key insights into sexual maturation
• Regulation of macrophage polarization by metformin through inhibition of TLR4/NF-κB pathway to improve pre-eclampsia
• Dissection of pro-tumoral macrophage subtypes and immunosuppressive cells participating in M2 polarization
• Polyphenolic Hispolon Derived from Medicinal Mushrooms of the Inonotus and Phellinus Genera Promotes Wound Healing in Hyperglycemia-Induced Impairments
• Immune mechanisms and shared immune targets in neurodegenerative diseases
• PET/CT in Inflammatory and Auto-immune Disorders: Focus on Several Key Molecular Concepts, FDG, and Radiolabeled Probe Perspectives
• The immune landscape in apical periodontitis: From mechanism to therapy
• Inflammation in cardiovascular-kidney-metabolic syndrome: key roles and underlying mechanisms–a comprehensive review
• Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription. [europepmc]
• Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment. [europepmc]
• Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization. [europepmc]
• Progression on the Roles and Mechanisms of Tumor-Infiltrating T Lymphocytes in Patients With Hepatocellular Carcinoma. [europepmc]
• Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO. [europepmc]
• Macrophage Polarization and Its Role in Liver Disease. [europepmc]
• Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA Sequencing. [europepmc]
• Multinucleated Giant Cells: Current Insights in Phenotype, Biological Activities, and Mechanism of Formation. [europepmc]
• LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma. [europepmc]
• Tumor-Associated Macrophages and Ovarian Cancer: Implications for Therapy. [europepmc]
• The Good and the Bad: Monocytes' and Macrophages' Diverse Functions in Inflammation. [europepmc]
• Dissecting the treatment-naive ecosystem of human melanoma brain metastasis. [europepmc]
• The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies. [europepmc]
• Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages. [europepmc]
• Macrophage polarization in diabetic wound healing. [europepmc]
• Engineering homologous platelet-rich plasma, platelet-rich plasma-derived exosomes, and mesenchymal stem cell-derived exosomes-based dual-crosslinked hydrogels as bioactive diabetic wound dressings. [europepmc]
• The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells. [europepmc]
• Impact of Lipid Metabolism on Macrophage Polarization: Implications for Inflammation and Tumor Immunity. [europepmc]
• The role of macrophages polarization in sepsis-induced acute lung injury. [europepmc]
• The role of AMPK in macrophage metabolism, function and polarisation. [europepmc]
• Nanotechnology's frontier in combatting infectious and inflammatory diseases: prevention and treatment. [europepmc]
• Macrophage polarization: an important role in inflammatory diseases. [europepmc]
• Macrophage polarization and its impact on idiopathic pulmonary fibrosis. [europepmc]
• Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti-PD-1 therapy in hepatocellular carcinoma. [europepmc]
• Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances. [europepmc]