2006/01/01 by Knut Reinert, Oliver Kohlbacher, Reinert, Knut +11
Biochemistry, Genetics and Molecular Biology · Chemistry · #Advanced Proteomics Techniques and Applications #C++ #Differential expression #Mass Spectrometry Techniques and Applications #Metabolomics and Mass Spectrometry Studies #Proteomics
paper · doi:10.4230/dagsemproc.05471.13
openalex publication_date 2006/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
In the talk we describe the freely available software library OpenMS which is currently under development at the Freie Universität Berlin and the Eberhardt-Karls Universität Tübingen. We give an overview of the goals and problems in differential proteomics with HPLC and then describe in detail the implemented approaches for signal processing, peak detection and data reduction currently employed in OpenMS. After this we describe methods to identify the differential expression of peptides and propose strategies to avoid MS/MS identification of peptides of interest. We give an overview of the capabilities and design principles of OpenMS and demonstrate its ease of use. Finally we describe projects in which OpenMS will be or was already deployed and thereby demonstrate its versatility.