Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways

2015/06/20 by Eun-Mi Noh, Eun‐Mi Noh, Yeon-Ju Park +24 · 64 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · Medicine · Nursing · #Antioxidant #Biochemistry #Biology #Cancer #Cancer cell #Cancer research #Cell biology #Chemistry #Fisetin #Flavonoid #Internal medicine #MAPK/ERK pathway #Matrix metalloproteinase #Medicine #Metastasis #Pomegranate: compositions and health benefits #Protease and Inhibitor Mechanisms #Protein kinase C #Signal transduction #Tannin, Tannase and Anticancer Activities #Tetradecanoylphorbol Acetate #p38 mitogen-activated protein kinases

paper · doi:10.1016/j.ejphar.2015.06.038

published in European Journal of Pharmacology 764, 79-86 (Elsevier BV)

openalex publication_date 2015/06/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Citations

• Systematic risk behavior of financially distressed firms

Cited by

• Exploring the molecular targets of dietary flavonoid fisetin in cancer
• Anti-Tumor Effect of Pinus massoniana Bark Proanthocyanidins on Ovarian Cancer through Induction of Cell Apoptosis and Inhibition of Cell Migration. [europepmc]
• Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells. [europepmc]
• Polyphenolic Profile and Targeted Bioactivity of Methanolic Extracts from Mediterranean Ethnomedicinal Plants on Human Cancer Cell Lines. [europepmc]
• Exploring the molecular targets of dietary flavonoid fisetin in cancer. [europepmc]
• Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles. [europepmc]
• Cell Signaling Pathway in 12-O-Tetradecanoylphorbol-13-acetate-Induced LCN2 Gene Transcription in Esophageal Squamous Cell Carcinoma. [europepmc]
• Anti‑cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mTOR pathway: In vitro and in vivo studies. [europepmc]
• Nrf2⁻ARE Signaling Acts as Master Pathway for the Cellular Antioxidant Activity of Fisetin. [europepmc]
• Fisetin Suppresses Human Osteosarcoma U-2 OS Cell Migration and Invasion via Affecting FAK, uPA and NF-ĸB Signaling Pathway In Vitro . [europepmc]
• Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential. [europepmc]
• Methyl Linderone Suppresses TPA-Stimulated IL-8 and MMP-9 Expression Via the ERK/STAT3 Pathway in MCF-7 Breast Cancer Cells. [europepmc]
• Fisetin: An anticancer perspective. [europepmc]
• Bruton's agammaglobulinemia tyrosine kinase (Btk) regulates TPA‑induced breast cancer cell invasion via PLCγ2/PKCβ/NF‑κB/AP‑1‑dependent matrix metalloproteinase‑9 activation. [europepmc]
• Fisetin Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells via the Inhibition of YAP. [europepmc]
• Fisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis. [europepmc]
• Downregulation of matriptase suppresses the PAR‑2/PLCγ2/PKC‑mediated invasion and migration abilities of MCF‑7 breast cancer cells. [europepmc]
• Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review. [europepmc]
• The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment. [europepmc]
• Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies. [europepmc]
• Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics. [europepmc]
• Novel PEGylated cholephytosomes for targeting fisetin to breast cancer: in vitro appraisal and in vivo antitumoral studies. [europepmc]
• Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling. [europepmc]
• Role of Fisetin in Selected Malignant Neoplasms in Women. [europepmc]
• Fisetin Inhibits UVA-Induced Expression of MMP-1 and MMP-3 through the NOX/ROS/MAPK Pathway in Human Dermal Fibroblasts and Human Epidermal Keratinocytes. [europepmc]
• Targeting the MAPK signaling pathway: implications and prospects of flavonoids in 3P medicine as modulators of cancer cell plasticity and therapeutic resistance in breast cancer patients. [europepmc]